Fatal nefopam overdose

Nefopam Hydrochloride: A Fatal Overdose.

Nefopam is a non-opiate analgesic commonly used for the treatment of moderate to severe pain. A case of a 37-year-old male who was found dead in the morning is presented. An autopsy was performed and femoral venous blood, heart blood, urine, and vitreous humor were submitted for toxicological analysis. A general drug screen detected the presence of nefopam, caffeine, nicotine, citalopram, gabap...

Fatal digoxin overdose.

Overdosage with cardiac glycosides is well documented, but not usually fatal. A case is described in which cardiac arrest in asystole was associated with a serum digoxin level of 50-4 microgram/1, the highest concentration yet reported after oral administration.

Non-Fatal Amlodipine and Insulin Overdose in an Elderly Person

Prevention of fatal opioid overdose.

OPIOID OVERDOSE IS A BURGEONING PUBLIC HEALTH crisis, accounting for at least 16 000 deaths annually in the United States. Opioid overdose occurs across sex, ethnic, age, and geographic strata and involvesbothmedicalandnonmedicalopioiduse.Todate, federal government response has focused primarily on monitoringandsecuringthedrugsupply. ThisViewpointsuggestsvariousstepsnecessarytosupportamorecompr...

Two cases of fatal zopiclone overdose.

Two cases of death due to the ingestion of zopiclone are presented. Quantitative determinations of zopiclone yielded 1.4-3.9 mg/L in the blood, 0.81 and 8.7 mg/kg in the liver, and 13.5 and 133 mg in the stomach contents. Drug concentrations were interpreted relative to the case findings, published data, and a limited evaluation of therapeutic concentrations found in two cases of therapeutic zo...